Melasma (or the mask of pregnancy when present in pregnant women) is a tan or dark skin discoloration. Although it can affect anyone, melasma is particularly common in women, especially pregnant women and those who are taking oral or patch contraceptives or hormone replacement therapy (HRT) medications. It is also prevalent in men and women of Native American descent (on the forearms) and in men and women of German/Russian and Jewish descent (on the face).
The symptoms of melasma are dark, irregular patches commonly found on the upper cheek, nose, lips, upper lip, and forehead. These patches often develop gradually over time. Melasma does not cause any other symptoms beyond the cosmetic discoloration.
Melasma is thought to be the stimulation of melanocytes or pigment-producing cells by the female sex hormones estrogen and progesterone to produce more melanin pigments when the skin is exposed to sun. Women with a light brown skin type who are living in regions with intense sun exposure are particularly susceptible to developing this condition.
Genetic predisposition is also a major factor in determining whether someone will develop melasma.
The incidence of melasma also increases in patients with thyroid disease. It is thought that the overproduction of melanocyte-stimulating hormone (MSH) brought on by stress can cause outbreaks of this condition. Other rare causes of melasma include allergic reaction to medications and cosmetics.
Melasma is usually diagnosed visually or with assistance of a Wood’s lamp (340 – 400 nm wavelength). Under Wood’s lamp, excess melanin in the epidermis can be distinguished from that of the dermis.
The discoloration usually disappears spontaneously over a period of several months after giving birth or stopping the oral contraceptives or hormone replacement therapy.
Treatments to hasten the fading of the discolored patches include:
- Topical depigmenting agents, such as hydroquinone (HQ) prescription (4%) strength. HQ is a chemical that inhibits tyrosinase, an enzyme involved in the production of melanin.
- Tretinoin, an acid that increases skin cell (keratinocyte) turnover. This treatment cannot be used during pregnancy.
- Azelaic acid (20%), thought to decrease the activity of melanocytes.
- Facial peel with alpha hydroxyacids or chemical peels with glycolic acid.
- Laser treatment. A Wood’s lamp test should be used to determine whether the melasma is epidermal or dermal. If the melasma is dermal, CO2 Fraxel laser has been shown in studies to provide improvement in many patients. Intense pulsed light has also been effective in the treatment of melasma. Dermal melasma is generally unresponsive to most treatments, and has only been found to lighten with products containing mandelic acid (such as Triluma cream) or CO2 Fraxel laser.
In all of these treatments the effects are gradual and a strict avoidance of sunlight is required. Sunscreen is the initial line of defense to prevent discoloration. Ideal sunscreens protect against harmful UVA and UVB rays. The use of broad-spectrum sunscreens with physical blockers is preferred over that with only chemical blockers. A physical sun block contains Zinc, Titanium Dioxide, or Iron Oxides, or a combination of these. These ingredients reflect UV light and have anti-inflammatory properties. Chemical sunscreens absorb UV light to protect the skin and both UVA & UVB are capable of stimulating pigment production.
Cosmetic cover-ups can also be used to reduce the appearance of melasma.
Here at this clinic a comprehensive anti melasma regimen has been especially designed for your convenience. Please call today for your special consultation.